Laboratory/Faculty

Laboratory of Cell Regulation
Group of Genetics

ProfessorShizue Ohsawa
Dissecting the mechanism of Tissue growth regulation
Assisitant ProfessorEmi Maekawa
▶Laboratory HP
Japanese
  

Multicellular organisms accomplish normal tissue growth in a highly reproducible manner even in the presence of various perturbations such as genetic mutations and environmental fluctuations. Cell-cell communication within the growing tissue ensures robust coordination of tissue growth and homeostasis by regulating cell proliferation and cell death. Using a powerful genetic model Drosophila, we are now dissecting the mechanism of robust coordination of tissue growth and homeostasis through cell-cell communications. In addition, there are growing evidence suggesting that cancer development is also achieved by not only a series of genetic alterations, but also cell-cell communications. We are now dissecting the mechanism of cancer development through cell-cell communication. Our goal is to understand the principle of multicellular communities coordinated by cell-cell communications.

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References

  1. Ohsawa et al., “Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis” Dev. Cell, 44, 284-296 (2018) (Invited Review)
  2. Akai et al., “Wingless signaling regulates winner/loser status in Minute cell competition” Genes Cells, 23, 234-240 (2018)
  3. Yamamoto et al., The ligand Sas and its receptor PTP10D drive tumour-suppressive cell competition. Nature, 542, 246-250 (2017)
  4. Nakamura et al., “Mitochondrial defects trigger proliferation of neighbor-ing cells via senescence-associated secretory phenotype in Drosophila” Nature Communications, 5, 5264 (2014)
  5. Ohsawa et al., “Mitochondrial defect drives non-autonomous tumour progression via Hippo signalling in Drosophila” Nature, 490, 547-551 (2012)
  6. Ohsawa et al., “Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila” Developmental Cell, 20, 315-328 (2011)

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