論文紹介

第28回論文紹介(2016.11更新)

グループ名
分子神経生物学グループ(行動遺伝学チーム)

著者

Moonjung Hyun, Kristen Davis, Inhwan Lee, Jeongho Kim, Catherine Dumur, Young-Jai You


タイトル(英)
Fat Metabolism Regulates Satiety Behavior in C. elegans

タイトル(日)
線虫C. elegansにおいて、満腹応答は脂肪代謝によって制御される

発表された専門誌
SCIENTIFIC REPORTS, 6:24841 (2016)

Animals change feeding behavior depending on their metabolic status; starved animals are eager to eat and satiated animals stop eating. C. elegans exhibits satiety quiescence that mimics many aspects of post-prandial sleep in mammals. Here we show that this feeding behavior depends on fat metabolism mediated by the SREBP-SCD pathway, an acetyl-CoA carboxylase (ACC) and certain nuclear hormone receptors (NRs). Mutations of the genes in the SREBP-SCD pathway reduce satiety quiescence. An RNA interference (RNAi) screen of the genes that regulate glucose and fatty acid metabolism identified an ACC necessary for satiety quiescence in C. elegans. ACC catalyzes the first step in de novo fatty acid biosynthesis known to be downstream of the SREBP pathway in mammals. We identified, by microarray, 28 NRs whose expression changes during refeeding after being starved. When individually knocked down by RNAi, 11 NRs among 28 affect both fat storage and satiety behavior. Our results show that the major fat metabolism pathway regulates feeding behavior and NRs could be the mediators to link the feeding behavior to the metabolic changes.


図1:満腹静止(Satiety quiescence)には脂肪が必要。A, B, 脂肪酸合成能が低下した 個体(sbp-1変異体、 fat-6;fat-7二重変異体、およびsbp-1の RNAi処理)では、満腹静止の時間が低下する。C, 変異体でも、脂肪酸(オレイン酸)を投与すれば満腹静止の時間が回復する。


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