論文紹介

第32回論文紹介(2018.10更新)

グループ名
代謝行動遺伝学グループ
著者

Kristen Davis, Young-In Choi, Jeongho Kim, Young-Jai You

タイトル(英)
Satiety behavior is regulated by ASI/ASH reciprocal antagonism
タイトル(日)
飽食挙動は、ASI / ASH相互拮抗作用によって調節される
発表された専門誌
Scientific Reports, 8(1):6918, 2018

Appropriate decision-making is essential for ensuring survival; one such decision is whether to eat. Overall metabolic state and the safety of food are the two factors we examined using C. elegans to ask whether the metabolic state regulates neuronal activities and corresponding feeding behavior. We monitored the activity of sensory neurons that are activated by nutritious (or appetitive) stimuli (ASI) and aversive stimuli (ASH) in starved vs. well-fed worms during stimuli presentation. Starvation reduces ASH activity to aversive stimuli while increasing ASI activity to nutritious stimuli, showing the responsiveness of each neuron is modulated by overall metabolic state. When we monitored satiety quiescence behavior that reflects the overall metabolic state, ablation of ASI and ASH produce the opposite behavior, showing the two neurons interact to control the decision to eat or not. This circuit provides a simple approach to how neurons handle sensory conflict and reach a decision that is translated to behavior.

図1/Fig1:

Proposed model for ASI and ASH activity influenced by internal and external cues. (A) Under well-fed conditions the balance between ASI and ASH favors the activity of ASH when nutrients and a noxious stimulus are present. (B) During fasting conditions the balance between ASI and ASH favors the activity of ASI when nutrients and a noxious stimulus are present.


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